19. may 2010
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White pearls of axis, such as DNA wraps around the Assembly is called histones (colored) Nucleosome presents a particular structure of the protein, which is responsible for regulating genes and condensing the nucleus of the cell DNA wires to fit. Researchers once thought nucleosomes regulated through the Histone gene tails (dotted lines), but a recent study showed that the core of the relevant structures.That finding sheds on how development should be made for the light and how the abnormal gene regulation may cause cancer.Courtesy of Karolin Luger Colorado State University.
Parabellum lab
Today, doctors test on an occasional basis, for one or two genes of a patient to help diagnose or treat a disease., in the future, they more than 20 000 genes. the key question is whether the doctors are able to use these entire genomes. one response comes from Stanford University School of Medicine research group led by Euan Ashley cardiologist. comprehensive healthy had analysed the person's full first — also one of the team of researchers — reducing the risk of transmitting diseases to predict his and atypical drugs answers. Research advances on that whole genome sequence may one day clinical role concept.
This work also supported the NIH's national Heart, Lung and Blood Institute, National Human Genome Research Institute; and the National Library of Medicine.
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Ashley profile
Abstract (Lancet, commencing on 1 May)
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When the molecule enters the cell of the outer membrane filters, membrane filters create a bag around which protrudes inwards. directed by protein, called dynamin, bag then may use a Vesicle, pinched, equipped with a molecule to the correct location inside a cell. to better understand the how dynamin run it bag pinching pöytäviinimarkkinoiden, cell biologist Sandra Schmid at the Research team headed by the Institute shall be determined in accordance with the structure of the Group proposes that the dynamin "a collar" at bag base twists ever tighter controls before the Vesicle appears free.Because the cells to absorb many of the drugs through the vesicles, the discovery could lead to new drug delivery method (s).
This work was supported by the NIH's National Institute of diabetes and digestive and Kidney diseases, and the National Institute of mental health.
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Schmid lab
The article abstract (April 28 online issue of Nature),
Human Genome Project has been carried out, because scientists have been taken by the majority of our genes and their protein amounts of data. they know where the genes are located in which mutations lead to disease and how proteins interact with systems biologist Ravi. now Iyengar and his colleagues at Mount Sinain School of Medicine is integrated with all this information framework that helped them understand how drugs can produce similar in people with congenital heart condition seen arrhythmias may be a side effect of. in this context, detect and predict other drugs dangerous steps.
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Iyengar lab
The article abstract (April 20 issue of Science Signaling) from
Edward Marcotte and John Wallingford, University of Texas at Austin, researchers studied under the direction of the distantly related organisms, such as frogs and worms that try to, you can learn more about human genes, including the measured Data to the disease,. what genes work together as a team of researchers of these organisms is able to identify groups of similar gene in humans then could determine the scientists what some of these human genes do by looking at the known to the other team members are expected to disclose the method function. tasks and other human genes and to identify new targets for drug therapy.
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Marcotte lab
Wallingford lab
Abstract (April 6, commencing on the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES)
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