16. June 2010
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If a picture is worth a thousand words, then this is about 10 000. it makes visible the known molecular and genetic interactions take place inside our bodies After collecting thousands. this information from the database, researchers used BioGrid computer program called Cytoscape map one picture in this images is called. Technically network wiring diagrams, but the Cytoscape creator Trey Ideker somewhat jokingly calls on them to "hairballs" because they can be complex, intricate and difficult to Tease apart. Fortunately, Cytoscape has tools to help Researchers will examine specific interactions between species or sick and diseased cells such as differences between. Courtesy of Keiichiro Ono, University of California-San Diego.
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Cytoscape
Cell biologist Anders N r and Massachusetts General Hospital found family — is called microRNAs miR-33 — which serves as a basis for its host gene keep their blood cholesterol levels.After a series of experiments, the researchers determined that they may reduce their blood cholesterol levels in mice by the cellular the molecule, which prevented the operation from the Mir-33.By the same molecule high dry matter of diet, mice, researchers boosted rodents levels of cholesterol and HDL or "good" with cause adverse effects in the verotasonsa LDL or "bad" cholesterol.These findings could lead to heart in the future.
Research was supported by the NIH's National Institute of diabetes and digestive and Kidney diseases.
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N r lab
Abstract (May 13 online issue of Science)
Antibodies are the most promising treatments for certain forms of cancer patients, but they must be taken of the deadly, reveals healthy tissues and side-effects of the drug increases the risk of the material, the biologist. now scientists and cancer biologists Pacific Northwest National Laboratory, led by team is Lei Chenghong packed anticancer antibodies must be supplied directly to a heavy dose of mice porous silica particles method melanoma tumours growth slowed and extended the lifetime of a diseased mice. Lei's now Test other types of tumours particles and will study the method of human clinical trials.
This work also supported by NIH's National Cancer Institute.
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Law profile
Abstract (JACS, commencing in May 26)
Active beam of light on the Johns Hopkins School of Medicine Denise Montell and Klaus Hahn, University of North Carolina, Chapel Hill, the biologist, are required to appear in living tissues, cells that have been resolved in version signaling movement. protein, called the Rac used to activate the light in this case, one of the fruit fly. munasarjasta cell size a set of cells in the shop and showed that the adjacent cells in the message, and then do the advance will help you understand the Director. researchers of biological processes, including cell movement, development, immune and cancer metastasis.
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Montell lab
The lab Hahn
Abstract (June issue of nature cell Biology)
Many diseases, such as type 2 diabetes is caused by genes and environmental factors. But these factors — such as nutrition and pathogens and toxins, as allergens — it is difficult to analyze. Now, Atul Butte, led by team is Stanford University School of Medicine, pediatrician and computer scientist has developed a method for PCs and publicly available data, how to contribute to the development of the factors examined, 226 diabetes researchers using Certain comments, such as PCB, toxin was strongly associated with the illness. others, such as nutrients beta-carotene, protected against the person (s). this new "enviromics" technology, which reflects the genome-wide studies, could be applied to other complex diseases such as obesity, hypertension and heart diseases.
This work also supported the NIH's National Library of medicine and the National Institute on aging.
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District profile
The article abstract (May 20, the issue of PLoS one) from the
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